In New York in the 1950s, John Winter, a policeman who is a veteran of the Second World War and has a particular "sixth sense", is called to solve the case of a serial killer who is terrorizing the city. Meanwhile, in the future, Nathan Never and his colleagues are involved in the hunt for two dangerous criminals who belong to Orange, the cynical and ruthless new lady of Sub City, the citadel of crime. But how is the New York of John Winter's past connected to the megalopolis of Special Agent Alpha's future? The answer is hidden somewhere, in the basement of Sub City To carry out the investigation into the "berserker", a drug capable of enormously increasing the aggressiveness and muscular strength of those who take it, Agenzia Alfa forms an alliance with Orange, the woman who shares control of organized crime in Sub City with The King. The pact is simple: Orange undertakes to ensure that the "berserker" no longer crosses the borders of the citadel of crime, and Nathan and Nicole will have to help Emma and Ray, Orange's two henchmen, to find Bambino, a dangerous brainless fighter who has escaped the control of the ruler of Sub City. Meanwhile, in 1950s New York, a stunned John Winter is about to finally come face to face with the mysterious serial killer known as "the Ogre"... Having allied themselves with Orange, Sub City's crime lord, Nathan and Nicole, traveling through the underground mazes of the citadel, accidentally came across a mysterious physical phenomenon: a space-time anomaly. The gap seems to be able to connect the East City with one of the possible pasts of the United States of the 1950s... At this point, it is important to understand how to keep the phenomenon under control, and above all who will have to manage it... The world of the past and the world of the future have met! But the consequences of this event went far beyond what Nathan Never and all the members of Agenzia Alfa could have thought... An unprecedented catastrophe will affect everyone, every life will be indelibly marked by this experience... Urania has truly fallen! The gigantic cylinder of iron and steel suddenly reappeared in the sky above the East City and collapsed to the ground, causing millions of victims, giving the final blow to a metropolis already in its death throes. The world of Special Agent Alpha has never appeared so dark and desperate, a wounded world that still wonders the reason for all these deaths and clings to the hope of still finding survivors under the rubble Inside Urania, the immense orbiting station that inexplicably crashed into the East City, the security corps of the Proconsuls documented an incredible flood of people Ordinary people who decided to defy the law and the ban on entering the structure; a sort of pilgrimage to hope for the redemption of one's sins and healing from one's illnesses. But in the images shot by the Proconsuls, Nathan notices above all a figure who stands aside, a man covered in bandages who shouldn't be there, who shouldn't even be alive Regardless of Solomon Darver's orders, Nathan decides to enter the wreck to finally give an answer to his questions, to clarify his doubts, to seek peace, perhaps, but above all revenge!